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- Title
Molecular characterization of Japanese encephalitis virus strains prevalent in Chinese swine herds.
- Authors
Hao Zheng; Tongling Shan; Yu Deng; Chunqing Sun; Shishan Yuan; Yang Yin; Guangzhi Tong
- Abstract
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis in Asia and domestic pigs serve as the amplifying hosts. In the present study, the full genomic sequences of two JEV strains (HEN0701 and SH0601) isolated from pigs in China were determined and compared with other 12 JEV strains deposited in GenBank. These two strains had an 88.8% nucleotide sequence similarity and 97.9% deduced amino acid sequence homology. HEN0701 had high nucleotide sequence and high amino acid sequence identity with genotype I (GI) strains, while SH0601 had high nucleotide sequence and high amino acid sequence identity with GUI strains at both the gene and full genome levels. Further phylogenetic analysis showed that HEN0701 belonged to the JEV GI group and SH0601 was classified as a Gill strain. Analysis of codon usage showed there were a few differences between the GI and GIII strains in nucleotide composition and codon usage for the open reading frames.
- Publication
Journal of Veterinary Science, 2013, Vol 14, Issue 1, p27
- ISSN
1229-845X
- Publication type
Academic Journal
- DOI
10.4142/jvs.2013.14.1.27