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- Title
Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.
- Authors
Soon-Hee Lee; Yong Heo; Young-ChuI Kim
- Abstract
Historically, German chamomile (GC) oil has been used for treatment of skin disorders. BALB/c mice were sensitized twice a week with 100 μtL of 1% 2,4-dinitrochlorobenzene (DNCB) and challenged twice the following week with 100 μL of 0.2% DNCB for atopic dermatitis induction. Thereafter, 3% CC oil was applied daily (70 μL, 6 times week) on the dorsal skin for 4 weeks. Saline or jojoba oil was used for the control mice. Blood was collected after second DNCB challenge, and at 2 and 4 weeks after initiating oil application. Serum IgE levels were significantly lowered in the GC oil application group at the end of the 4-week application period. The CC oil application for 4 weeks resulted in reduction in serum IgG1 level compared with that after 2-week application. The GC oil application group showed a significantly lower serum histamine level than the control group 2 weeks after oil application. Scratching frequency of the GC oil application group was significantly lower than either control groups. This study is to demonstrate CC oil's immunoregulatory potential for alleviating atopic dermatitis through influencing of Th2 cell activation.
- Publication
Journal of Veterinary Science, 2010, Vol 11, Issue 1, p35
- ISSN
1229-845X
- Publication type
Academic Journal
- DOI
10.4142/jvs.2010.11.1.35