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Title
Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.
Authors
McCluskey, James D; Sava, Dmytro; Harbison, Stephen C; Muro-Cacho, Carlos A; Giffe, Johnson T; Ping, Xu; Harbison, Raymond D
Abstract
Inhibitors of the nuclear enzyme poly (ADP-ribose) polymerase (PARP-1) have been demonstrated to attenuate pathophysiologic conditions associated with oxidative stress, specifically with carbon tetrachloride (CT)-induced hepatotoxicity.
Publication
International journal of critical illness and injury science, 2011, Vol 1, Issue 2, p97