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- Title
Liquid chromatographic determinations of meta-chlorobenzoic acid in bupropion hydrochloride.
- Authors
Sinha, Sukumar; Parashar, Vikas; Reddy, K Swamy; Khan, Mohammad A; Haque, S K Manirul
- Abstract
A simple, sensitive method for the determination of meta-chlorobenzoic acid in bupropion hydrochloride is described. Chromatographic separation of m-chlorobenzoic acid is achieved using a mobile phase consisting of n-hexane and ethanol (1000:50, v/v) at a flow rate of 1.0 ml/min on a Chiralpak ADH (250 × 4.6 mm). Absorbance is monitored at 235 nm. The method is linear for m-chlorobenzoic acid over concentration range of LOQ, 5.0 μg/ml to 15.0 μg/ml for m-chlorobenzoic acid with correlation coefficient greater than 0.99. This method is more selective and accurate than United States Pharmacopoeia method for the determination of m-chlorobenzoic acid in bupropion hydrochloride.
- Publication
Journal of natural science, biology, and medicine, 2013, Vol 4, Issue 2, p435
- ISSN
0976-9668
- Publication type
Journal Article
- DOI
10.4103/0976-9668.117018