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- Title
APOA1 gene polymorphisms in the South Asian immigrant population in the United States.
- Authors
Henkhaus, Rebecca S; Dodani, Sunita; Manzardo, Ann M; Butler, Merlin G
- Abstract
Coronary artery disease (CAD) is a leading cause of death in the United States. South Asian immigrants (SAIs) from the Indian subcontinent living in the US are disproportionately at higher risk of CAD than other immigrant populations. Unique genetic factors may predispose SAIs to increased risk of developing CAD when adopting a Western lifestyle including a higher-fat diet, more sedentary behavior and additional gene-environment interactions. SAIs are known to have low levels of the protective high density lipoprotein (HDL) and an altered function for Apo-lipoprotein A-1 (ApoA1), the main protein component of HDL cholesterol. One gene that may be genetically distinctive in this population is APOA1 which codes for ApoA-1 protein, a potentially important contributing factor in the development of CAD.
- Publication
Indian journal of human genetics, 2011, Vol 17, Issue 3, p194
- ISSN
0971-6866
- Publication type
Journal Article
- DOI
10.4103/0971-6866.92103