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- Title
Validation of a diagnostic microarray for human papillomavirus: coverage of 102 genotypes.
- Authors
Arron, Sarah Tuttleton; Skewes-Cox, Peter; Do, Phong H; Dybbro, Eric; Da Costa, Maria; Palefsky, Joel M; Derisi, Joseph L
- Abstract
Papillomaviruses have been implicated in a variety of human diseases ranging from common warts to invasive carcinoma of the anogenital mucosa. Existing assays for genotyping human papillomavirus are restricted to a small number of types. Here, we present a comprehensive, accurate microarray strategy for detection and genotyping of 102 human papillomavirus types and validate its use in a panel of 91 anal swabs. This array has equal performance to traditional dot blot analysis with the benefits of added genotype coverage and the ability to calibrate readout over a range of sensitivity or specificity values.
- Publication
Journal of nucleic acids, 2011, Vol 2011, p756905
- ISSN
2090-021X
- Publication type
Journal Article
- DOI
10.4061/2011/756905