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- Title
Neuroimaging measures as endophenotypes in Alzheimer's disease.
- Authors
Braskie, Meredith N; Ringman, John M; Thompson, Paul M
- Abstract
Late onset Alzheimer's disease (AD) is moderately to highly heritable. Apolipoprotein E allele ε4 (APOE4) has been replicated consistently as an AD risk factor over many studies, and recently confirmed variants in other genes such as CLU, CR1, and PICALM each increase the lifetime risk of AD. However, much of the heritability of AD remains unexplained. AD is a complex disease that is diagnosed largely through neuropsychological testing, though neuroimaging measures may be more sensitive for detecting the incipient disease stages. Difficulties in early diagnosis and variable environmental contributions to the disease can obscure genetic relationships in traditional case-control genetic studies. Neuroimaging measures may be used as endophenotypes for AD, offering a reliable, objective tool to search for possible genetic risk factors. Imaging measures might also clarify the specific mechanisms by which proposed risk factors influence the brain.
- Publication
International journal of Alzheimer's disease, 2011, Vol 2011, p490140
- ISSN
2090-0252
- Publication type
Journal Article
- DOI
10.4061/2011/490140