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- Title
Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer.
- Authors
Masuda, Kenta; Banno, Kouji; Yanokura, Megumi; Kobayashi, Yusuke; Kisu, Iori; Ueki, Arisa; Ono, Asuka; Asahara, Nana; Nomura, Hiroyuki; Hirasawa, Akira; Susumu, Nobuyuki; Aoki, Daisuke
- Abstract
Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene. An aberration in the MMR gene prevents accurate repair of base mismatches produced during DNA replication. This phenomenon can lead to an increased frequency of errors in target genes involved in carcinogenesis, resulting in cancerization of the cell. On the other hand, aberrant DNA methylation is thought to play a key role in sporadic endometrial carcinogenesis. Hypermethylation of unmethylated CpG islands in the promoter regions of cancer-related genes associated with DNA repair leads to the cell becoming cancerous. Thus, both genetic and epigenetic changes are intricately involved in the process through which cells become cancerous. In this review, we introduce the latest findings on the DNA mismatch repair pathway in endometrial cancer.
- Publication
Molecular biology international, 2011, Vol 2011, p256063
- ISSN
2090-2190
- Publication type
Journal Article
- DOI
10.4061/2011/256063