The Research Progress of Tumor Necrosis Factor Alpha in Multiple Sclerosis and Remyelination.

LEI Xudan; XU Fei; LI Yuhao

Tumor necrosis factor (TNF)-α is a pleiotropic inflammatory cytokine, which is produced chiefly by activated macrophages. Two forms of TNF-α, soluble and transmembrane, can bind tumor necrosis factor receptor (TNFR) 1 or TNFR2, respectively. Recently, a concept has emerged that TNF-α/TNFR pathway plays an important role in the pathogenesis of multiple sclerosis and remyelination. TNFR1 induces death of oligodendrocytes via death receptor-mediated apoptosis, which leads to demyelination or other neurodegenerative changes. However, TNFR2 has a positive effect on multiple sclerosis. It facilitates the proliferation and differentiation of oligodendrocyte precursor cells, thus promoting remyelination.

TUMOR necrosis factors; MULTIPLE sclerosis research; MYELIN sheath; TUMOR necrosis factor receptors; OLIGODENDROGLIA

Tianjin Medical Journal, 2014, Vol 42, Issue 11, p1141

0253-9896

Academic Journal

10.3969/j.issn.0253-9896.2014.11.027