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- Title
Leptin reverses declines in satiation in weight-reduced obese humans.
- Authors
Kissileff, Harry R; Thornton, John C; Torres, Migdalia I; Pavlovich, Katherine; Mayer, Laurel S; Kalari, Vamsi; Leibel, Rudolph L; Rosenbaum, Michael
- Abstract
Individuals who are weight-reduced or leptin deficient have a lower energy expenditure coupled with higher hunger and disinhibition and/or delayed satiation compared with never-weight-reduced control subjects. Because exogenous leptin inhibits feeding in congenitally leptin-deficient humans, reduced leptin signaling may reduce the expression of feeding inhibition in humans.
- Publication
The American journal of clinical nutrition, 2012, Vol 95, Issue 2, p309
- ISSN
1938-3207
- Publication type
Journal Article
- DOI
10.3945/ajcn.111.012385