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- Title
Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children.
- Authors
Koletzko, Berthold; Lattka, Eva; Zeilinger, Sonja; Illig, Thomas; Steer, Colin
- Abstract
Blood and tissue long-chain polyunsaturated fatty acid (LC-PUFA) amounts, which have been associated with early development and lifelong health, depend on dietary intake and endogenous conversion of precursor fatty acids (FAs) by the enzymes Δ⁵-desaturase and Δ⁶-desaturase. Polymorphisms in the desaturase encoding genes FADS1 and FADS2 have been associated with several n-6 (omega-6) and n-3 (omega-3) FAs and especially with arachidonic acid (AA) amounts. Associations with docosahexaenoic acid (DHA), which is considered particularly important for brain and retina development, are hardly existent.
- Publication
The American journal of clinical nutrition, 2011, Vol 93, Issue 1, p211
- ISSN
1938-3207
- Publication type
Journal Article
- DOI
10.3945/ajcn.110.006189