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- Title
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
- Authors
Beaudin, Anna E; Abarinov, Elena V; Noden, Drew M; Perry, Cheryll A; Chu, Stephanie; Stabler, Sally P; Allen, Robert H; Stover, Patrick J
- Abstract
Folic acid supplementation prevents the occurrence and recurrence of neural tube defects (NTDs), but the causal metabolic pathways underlying folic acid-responsive NTDs have not been established. Serine hydroxymethyltransferase (SHMT1) partitions folate-derived one-carbon units to thymidylate biosynthesis at the expense of cellular methylation, and therefore SHMT1-deficient mice are a model to investigate the metabolic origin of folate-associated pathologies.
- Publication
The American journal of clinical nutrition, 2011, Vol 93, Issue 4, p789
- ISSN
1938-3207
- Publication type
Journal Article
- DOI
10.3945/ajcn.110.002766