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- Title
Increased expression of chymase in inflammatory polyps in elderly patients with functional bowel disorder.
- Authors
JIAN-MING RONG; HONG-ZAN JI; XIAO-WEI WU; QUAN SUN; MEI-XIA GUO; XIAO-BING XU; FANG-YU WANG
- Abstract
Chymase, a chymotrypsin-like protease, is a non angiotensin-converting enzyme (ACE) angiotensinII (AngII)-generating enzyme. The aim of the present study was to investigate whether chymase activity was increased in inflammatory polyps of elderly patients with functional bowel disorder (FBD). This study enrolled 45elderly patients with FBD and 44healthy control individuals. Expression of chymase in intestinal mucosa was assessed using fluorescence quantitative polymerase chain reaction and immunohistochemistry (IHC). IHC showed an increased number of chymase-positive mast cells in inflammatory polyps than in healthy intestinal mucosa (P<0.05). Compared with healthy mucosa, expression of chymase at the mRNA and protein level was significantly higher in inflammatory polyps. The frequencies of the chymase GGgenotype and the Gallele type were higher in the intestinal mucosa of patients with FBD compared with healthy controls (66.67 versus 40.91%, 81.11 versus 63.63%, both P<0.05). The frequency of the G allele type in the intestinal mucosa of the C4 subgroup of FBD was higher than that in the control group. However, in other FBD subgroups, there was no difference between patients and controls. Based on the fact that enhanced chymase expression was observed in inflammatory polyps of elderly patients with FBD relative to those in healthy controls, it was concluded that chymase has a significant role in the pathogenesis of inflammatory polyps in elderly patients with FBD.
- Publication
Experimental & Therapeutic Medicine, 2014, Vol 7, Issue 2, p371
- ISSN
1792-0981
- Publication type
Academic Journal
- DOI
10.3892/etm.2013.1444