Relationship between bone mineral density and inflammatory markers in postmenopausal patients.

HALİLZADE, Mohammad İbrahim; TAŞ, Emre Erdem

Aim: This study aimed to determine the effects of acute-phase reactants and other factors on osteoporosis in postmenopausal women and to investigate inflammation markers that can be used in early diagnosis. Materials and Methods: This study included 200 postmenopausal patients aged 40-65. Patients were divided into two groups: those with a bone mineral densitometry T-score below -2.5 (osteoporosis-positive) and above -2.5 (osteoporosis-negative). Patient demographics (age, parity, height, weight, body mass index (BMI - kg/m2), duration of menopause, education level [<University vs. =University], and occupation status [Working vs. Housewife/Pensioner]), complete blood count (hematocrit, white blood cell (WBC) count, neutrophil-to-lymphocyte (NLR) ratio), and serum biochemistry (low-density protein (LDL), vitamin D, and C-reactive protein (CRP)) levels were compared between the two groups. Results: The mean lumbar T-score in the osteoporosis-positive group was significantly lower than in the osteoporosis-negative group (-2.9±0.4 vs. -0.8±1.0, p<0.01). Age, height, duration of menopause, and occupation status did not differ between the groups. However, mean parity, weight, and BMI were significantly higher in the osteoporosis-negative group (p<0.01). Blood Htc, WBC, NLR, and serum CRP and vitamin D levels showed no significant differences, but serum LDL levels were significantly lower in the osteoporosis-positive group (p=0.03). Binary logistic regression indicated low parity (OR: 0.65; p=0.02) and high educational level (OR: 0.42, p=0.01) were independently associated with a reduced risk of osteoporosis. Conclusion: In our study, postmenopausal osteoporosis was not associated with serum inflammatory markers, and inflammatory markers were not valuable in predicting osteoporosis. However, postmenopausal osteoporosis was found to be closely related to parity, education level, weight and BMI.

LEUKOCYTES; OSTEOPOROSIS in women; BONE density; BODY mass index; BONE densitometry

Jinekoloji-Obstetrik & Neonatoloji Tip Dergisi, 2024, Vol 21, Issue 4, p335

1304-5512

Academic Journal

10.38136/jgon.1587956