Severe vitamin D deficiency is associated with increased risk of first trimester miscarriage in the Eastern Black Sea region of Türkiye.

BEZİRGANOGLU ALTUNTAS, Neslihan; BAKİ YILDIRIM, Sema; BAYOGLU TEKİN, Yesim

Aim: To measure 25-hydroxyvitamin D (25(OH)D) serum concentration among pregnant women in the first trimester and its association with first-trimester pregnancy loss in the Eastern Black Sea region of Türkiye. Materials and Methods: In this retrospective, cross-sectional study, we collected health records of pregnant women attending prenatal care at our department between March 2020 and December 2020. Serum 25 (OH)D levels were measured in the first trimester, and the patient's characteristics and the course of the pregnancy were analyzed. We investigated the association between maternal vitamin D deficiency and the risk of subsequent miscarriage. Results: The final analysis included 246 pregnant women, with 50 (20.3%) had a miscarriage in the first-timester. The prevalence of vitamin D deficiency was high in the group, with 78.5% of the study group having serum levels of 25(OH)D<20 ng/ml. The mean 25(OH)D concentration was 13.3±5.7 ng/ml in the miscarriage group, 15.5±6.4 ng/ml for control group. The miscarriage group had a statistically older maternal age, higher parity.and higher rate of severe vit D deficiency. Logistic regression showed that only severe vit D deficiency was associated with miscarriage. Conclusion: We found high rates of vitamin D deficiency in this region among pregnant women in the first trimester. Severe Vitamin D deficiency was associated with an increased risk of first-trimester miscarriage. These findings suggest that a more aggressive approach for sufficient vitamin D supplementation may be considered in this region.

VITAMIN D deficiency; FIRST trimester of pregnancy; MATERNAL age; PRENATAL care; PREGNANT women; PREGNANCY; MISCARRIAGE

Jinekoloji-Obstetrik & Neonatoloji Tip Dergisi, 2024, Vol 21, Issue 4, p285

1304-5512

Academic Journal

10.38136/jgon.1438323