Effects of Sulfonylureas Treatment on Apoptosis, Total Superoxide Dismutase activity and Some Biochemical Parameters in Type 2 Diabetic Patients.

Zaidan, Noor Khalid; Saifullah, Perry H.

The purpose of this analysis was to evaluate the the influence of anti-diabetic drugs (sulfonylureas) in type two diabetic patients and the risk of developing diabetes complications related to kidney disease (Diabetic Nephropathy ) compared to healthy subjects by measuring influence of some apoptosis factors ( serum Tumor necrosis factor soluble Receptor-1(TNF-R1) and TNF-related apoptosis-inducing ligand receptor-2 (TRAIL-R2)) concentrations, Serum Small mothers against decapentaplegic (Smad1 ) as anew marker of diabetic nephropathy (DN),Superoxide dismutase concentration (SOD),Glycated hemoglobin (HbA1c%), Fasting plasma glucose (FPG),insulin concentration, insulin resistance (IR),urea and creatinine .A samples of convenience composed of 17 type 2 diabetic patients with sulfonylureas monotherapy and 17 normal subjects above the age of 40 years were recruited . Age,duration of disease and body mass index (BMI) was created. The mean levels of Smad1 and TRAIL- R2 in diabetics with sulfonylureas treatment, they were significantly higher compared to control subjects, while the means of SOD have low level in diabetic subjects, and the mean levels of TNF-R1 and IR were non-significant in diabetic with Sulfonylureas treatment compared to control subjects.

CREATININE; PEOPLE with diabetes; SUPEROXIDE dismutase; TUMOR necrosis factors; DIABETIC nephropathies; DIABETES complications; UREA

Indian Journal of Forensic Medicine & Toxicology, 2020, Vol 14, Issue 2, p1050

0973-9122

Academic Journal

10.37506/ijfmt.v14i2.3046