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- Title
Roles of galectins in inflammatory bowel disease.
- Authors
Hokama, Akira; Mizoguchi, Emiko; Mizoguchi, Atsushi
- Abstract
Protein/carbohydrate interactions through specific protein families termed lectin control essential biological processes. Galectins, a family of animal lectins defined by shared amino acid sequence with affinity for beta-galactosides, appear to be functionally polyvalent in a wide range of biological activity. Recent studies have identified immunoregulatory roles of galectins in intestinal inflammatory disorders. Galectin-1 and galectin-2 contribute to the suppression of intestinal inflammation by the induction of apoptosis of activated T cells, whereas galectin-4 is involved in the exacerbation of this inflammation by specifically stimulating intestinal CD4+ T cells to produce IL-6. We review how different members of the galectins provide inhibitory or stimulatory signals to control intestinal immune response under intestinal inflammation.
- Publication
World journal of gastroenterology, 2008, Vol 14, Issue 33, p5133
- ISSN
1007-9327
- Publication type
Journal Article
- DOI
10.3748/wjg.14.5133