Title

Association of serum PD-L1 and IGFBP-2 levels with prognosis in patients with esophageal carcinoma.

Authors

Yun-Kui Huo; Xiu-Wen Yan; Ru-Xiong Bai; Fu Liu

Abstract

This study investigates the prognostic value of serum biomarkers PD-L1 and IGFBP-2 in patients with esophageal carcinoma. It finds a significant positive correlation between these biomarkers and established tumor markers CEA and CYFRA21-1. The 3-year survival rate for the patient cohort was 45.10%, with deceased patients showing significantly higher levels of PD-L1 and IGFBP-2. ROC analysis indicates a strong predictive value for these biomarkers, with combined use potentially enhancing diagnostic accuracy. Kaplan-Meier curves reveal lower survival rates for patients with high biomarker expression. The study suggests that PD-L1 and IGFBP-2 could be valuable for clinical management and prognostic evaluation of esophageal carcinoma patients.

Subjects

TUMOR markers; SURVIVAL rate; PROGRAMMED death-ligand 1; PROGNOSIS; BIOMARKERS

Publication

Pakistan Journal of Pharmaceutical Sciences, 2024, Vol 37, Issue 6, p1315

ISSN

1011-601X

Publication type

Academic Journal

DOI

10.36721/PJPS.2024.37.6.REG.1315-1321.1