Synthesis of some N-sulfonated derivatives of 1-[(E)-3-phenyl-2- propenyl]piperazine as suitable antibacterial agents.

Abbasi, Muhammad Athar; Ijaz, Mubashar; Aziz-ur-Rehman; Siddiqui, Sabahat Zahra; Shah, Syed Adnan Ali; Shahid, Muhammad; Fatima, Hina

In the planned research work, the nucleophilic substitution reaction of 1-[(E)-3-phenyl-2-propenyl]piperazine (1) was carried out with different sulfonyl chlorides (2a-g) at pH 9-10 to synthesize its different N-sulfonated derivatives (3a-g). The structures of the synthesized compounds were characterized by their proton-nuclear magnetic resonance (1HNMR), carbon-nuclear magnetic resonance (13C-NMR) and Infra Red (IR) spectral data, along with CHN analysis. The inhibition potential of the synthesized molecules was ascertained against two bacterial pathogenic strains i.e. Bacillus subtilis and Escherichia coli. It was inferred from the results that some of the compounds were very suitable inhibitors of these bacterial strains. Moreover, their cytotoxicity was also profiled and it was outcome that most of these molecules possessed moderate cytotoxicity.

PIPERAZINE; ANTIBACTERIAL agents; NUCLEOPHILIC substitution reactions; SULFONYL chlorides; MAGNETIC resonance; BACILLUS subtilis

Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, Issue 4, p1609

1011-601X

Academic Journal

10.36721/PJPS.2020.33.4.REG.1609-1616.1