Title

A Comprehensive Review of Aminochalcones.

Authors

Irfan, Rimsha; Mousavi, Shikufa; Alazmi, Meshari; Saleem, Rahman Shah Zaib; Verotta, Luisella; Muñoz-Torrero, Diego

Abstract

Chalcones, members of the flavonoid family, display a plethora of interesting biological activities including but not limited to antioxidant, anticancer, antimicrobial, anti-inflammatory, and antiprotozoal activities. The literature cites the synthesis and activity of a range of natural, semisynthetic, and synthetic chalcones. The current review comprehensively covers the literature on amino-substituted chalcones and includes chalcones with amino-groups at various positions on the aromatic rings as well as those with amino-groups containing mono alkylation, dialkylation, alkenylation, acylation, and sulfonylation. The aminochalcones are categorized according to their structure, and the corresponding biological activities are discussed as well. Some compounds showed high potency against cancer cells, microbes, and malaria, whereas others did not. The purpose of this review is to serve as a one-stop location for information on the aminochalcones reported in the literature in recent years.

Subjects

CHALCONES; CHALCONE; ALKENYLATION; CANCER cells; ACYLATION; ALKYLATION

Publication

Molecules, 2020, Vol 25, Issue 22, p5381

ISSN

1420-3049

Publication type

Academic Journal

DOI

10.3390/molecules25225381