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- Title
Synthesis and Pharmacological Studies of Unprecedented Fused Pyridazino[3',4':5,6][1,2,4]triazino[3,4- <i>b</i> ][1,3,4]thiadiazine Derivatives.
- Authors
Ali, Rania S; Saad, Hosam A
- Abstract
A novel fused system with three or four fused rings—pyridazino[3′,4′:5,6][1,2,4]triazino[4,3- b ][1,2,4,5]tetrazine and pyridazino[3′,4′:5,6][1,2,4]triazino[3,4- b ]pyrimido[4,5- e ][1,3,4]thiadiazine was obtained from the starting materials 4(6 H )-amino-3-hydrazino-7-(2-thienyl)pyridazino[3,4- e ][1,2,4]-triazine 2 and 9-amino-3-(2-thienyl)-2 H ,8 H -pyridazino[3′,4′:5,6][1,2,4]triazino[3,4- b ][1,3,4]thiadiazine-8-carbonitrile 12 . Each of the starting compounds was subjected to a number of cyclization reactions to obtain a series of new heterocyclic fused systems, 3 ⁻ 10 and 13 ⁻ 23 , via bifunctional reagents. Some of the synthesized compounds were screened against three cell lines including HepG2, HCT-116 and MCF-7 to discover their anticancer activity. The synthesized compounds were characterized depending on their elemental analyses and spectral data.
- Publication
Molecules (Basel, Switzerland), 2018, Vol 23, Issue 5
- ISSN
1420-3049
- Publication type
Journal Article
- DOI
10.3390/molecules23051024