Works matching DE "MOLECULAR hybridization"

Results: 225

Design, Synthesis, and Docking Simulation of 1,3,4-Thiadiazolyl-Isoindole Thioglycosides and Hydrazinyl Sugar Analogs as Potential Anticancer Agents Targeting EGFR Kinase.

Published in:

Polycyclic Aromatic Compounds, 2025, v. 45, n. 6, p. 1075, doi. 10.1080/10406638.2024.2432361

By:

El-Enazy, Ahad;
El-Bayaa, Mohamed N.;
El-Sofany, Walaa I.;
Alminderej, Fahad M.;
Albadri, Abuzar E.A.E;
El-Sayed, Wael A.

Publication type:

Article

Quinazoline Based HDAC Dual Inhibitors as Potential Anti-Cancer Agents.

Published in:

Molecules, 2022, v. 27, n. 7, p. 2294, doi. 10.3390/molecules27072294

By:

Dhuguru, Jyothi;
Ghoneim, Ola A.

Publication type:

Article

Structural Basis of 2-Phenylamino-4-phenoxyquinoline Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.

Published in:

Molecules, 2022, v. 27, n. 2, p. 461, doi. 10.3390/molecules27020461

By:

Makarasen, Arthit;
Patnin, Suwicha;
Vijitphan, Pongsit;
Reukngam, Nanthawan;
Khlaychan, Panita;
Kuno, Mayuso;
Intachote, Pakamas;
Saimanee, Busakorn;
Sengsai, Suchada;
Techasakul, Supanna

Publication type:

Article

Development of Phenothiazine Hybrids with Potential Medicinal Interest: A Review.

Published in:

Molecules, 2022, v. 27, n. 1, p. 276, doi. 10.3390/molecules27010276

By:

Posso, Marina C.;
Domingues, Fernanda C.;
Ferreira, Susana;
Silvestre, Samuel

Publication type:

Article

Design, Synthesis, and Anticancer Activity Studies of Novel Quinoline-Chalcone Derivatives.

Published in:

Molecules, 2021, v. 26, n. 16, p. 4899, doi. 10.3390/molecules26164899

By:

Guan, Yong-Feng;
Liu, Xiu-Juan;
Yuan, Xin-Ying;
Liu, Wen-Bo;
Li, Yin-Ru;
Yu, Guang-Xi;
Tian, Xin-Yi;
Zhang, Yan-Bing;
Song, Jian;
Li, Wen;
Zhang, Sai-Yang

Publication type:

Article

Synthesis and Evaluation of Chalcone-Quinoline Based Molecular Hybrids as Potential Anti-Malarial Agents.

Published in:

Molecules, 2021, v. 26, n. 13, p. 4093, doi. 10.3390/molecules26134093

By:

Vinindwa, Bonani;
Dziwornu, Godwin Akpeko;
Masamba, Wayiza

Publication type:

Article

Design, Synthesis and Anticancer Activity of a New Series of N -aryl- N ′-[4-(pyridin-2-ylmethoxy)benzyl]urea Derivatives.

Published in:

Molecules, 2021, v. 26, n. 12, p. 3496, doi. 10.3390/molecules26123496

By:

Hou, Shicheng;
Liang, Shishao;
Zhang, Chao;
Han, Yingmei;
Liang, Jianhui;
Hu, Hongyu;
Zhang, Xingeng;
Hu, Chun;
Liu, Xiaoping;
Zhang, Hong

Publication type:

Article

Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.

Published in:

Molecules, 2020, v. 25, n. 14, p. 3165, doi. 10.3390/molecules25143165

By:

de Freitas Silva, Matheus;
Tardelli Lima, Ellen;
Pruccoli, Letizia;
Castro, Newton G.;
Guimarães, Marcos Jorge R.;
da Silva, Fernanda M. R.;
Fonseca Nadur, Nathalia;
de Azevedo, Luciana Luiz;
Kümmerle, Arthur Eugen;
Guedes, Isabella Alvim;
Dardenne, Laurent Emmanuel;
Gontijo, Vanessa Silva;
Tarozzi, Andrea;
Viegas, Claudio;
Belluti, Federica

Publication type:

Article

Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives.

Published in:

Molecules, 2020, v. 25, n. 7, p. 1668, doi. 10.3390/molecules25071668

By:

Zulu, Ayanda I.;
Oderinlo, Ogunyemi O.;
Kruger, Cuan;
Isaacs, Michelle;
Hoppe, Heinrich C.;
Smith, Vincent J.;
Veale, Clinton G. L.;
Khanye, Setshaba D.;
Tsotinis, Andrew

Publication type:

Article

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy.

Published in:

Molecules, 2020, v. 25, n. 5, p. 1050, doi. 10.3390/molecules25051050

By:

Lei, Yuan;
Han, Sheng;
Yang, Yang;
Pannecouque, Christophe;
De Clercq, Erik;
Zhuang, Chunlin;
Chen, Fen-Er

Publication type:

Article

Toxicity and Antitumor Activity of a Thiophene–Acridine Hybrid.

Published in:

Molecules, 2020, v. 25, n. 1, p. 64, doi. 10.3390/molecules25010064

By:

Lisboa, Thaís;
Silva, Daiana;
Duarte, Sâmia;
Ferreira, Rafael;
Andrade, Camyla;
Lopes, Ana Luiza;
Ribeiro, Juliana;
Farias, Davi;
Moura, Ricardo;
Reis, Malu;
Medeiros, Karina;
Magalhães, Hemerson;
Sobral, Marianna

Publication type:

Article

Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules.

Published in:

Molecules, 2019, v. 24, n. 12, p. 2224, doi. 10.3390/molecules24122224

By:

Defant, Andrea;
Mancini, Ines;
Boga, Carla;
Micheletti, Gabriele

Publication type:

Article

Synthesis, Spectroscopic Characterization and Antimicrobial Potential of Certain New Isatin-Indole Molecular Hybrids.

Published in:

Molecules, 2017, v. 22, n. 11, p. 1958, doi. 10.3390/molecules22111958

By:

Al-Wabli, Reem I.;
Zakaria, Azza S.;
Attia, Mohamed I.

Publication type:

Article

Design and Antiproliferative Evaluation of Novel Sulfanilamide Derivatives as Potential Tubulin Polymerization Inhibitors.

Published in:

Molecules, 2017, v. 22, n. 9, p. 1470, doi. 10.3390/molecules22091470

By:

Dong-Jun Fu;
Ji-Feng Liu;
Ruo-Han Zhao;
Jia-Huan Li;
Sai-Yang Zhang;
Yan-Bing Zhang

Publication type:

Article

Chalcone Derivatives: Promising Starting Points for Drug Design.

Published in:

Molecules, 2017, v. 22, n. 8, p. 1210, doi. 10.3390/molecules22081210

By:

Gomes, Marcelo N.;
Muratov, Eugene N.;
Pereira, Maristela;
Peixoto, Josana C.;
Rosseto, Lucimar P.;
Cravo, Pedro V. L.;
Andrade, Carolina H.;
Neves, Bruno J.

Publication type:

Article

Molecular Hybridization-Guided One-Pot Multicomponent Synthesis of Turmerone Motif-Fused 3,30-Pyrrolidinyl-dispirooxindoles via a 1,3-Dipolar Cycloaddition Reaction.

Published in:

Molecules, 2017, v. 22, n. 4, p. 645, doi. 10.3390/molecules22040645

By:

Bing Lin;
Gen Zhou;
Yi Gong;
Qi-Di Wei;
Min-Yi Tian;
Xiong-Li Liu;
Ting-Ting Feng;
Ying Zhou;
Wei-Cheng Yuan

Publication type:

Article

Synthesis of 16 New Hybrids from Tetrahydropyrans Derivatives and Morita-Baylis-Hillman Adducts: In Vitro Screening against Leishmania donovani.

Published in:

Molecules, 2017, v. 22, n. 2, p. 207, doi. 10.3390/molecules22020207

By:

de Oliveira Sousa, Suervy Canuto;
da Câmara Rocha, Juliana;
de Souza Lima Keesen, Tatjana;
da Paz Silva, Everton;
de Assis, Priscilla Anne Castro;
de Oliveira, João Paulo Gomes;
Capim, Saulo Luís;
Xavier, Francisco José Seixas;
Marinho, Bruno Guimarães;
Silva, Fábio Pedrosa Lins;
Lima-Junior, Claudio Gabriel;
de Almeida Vasconcellos, Mário Luiz Araújo

Publication type:

Article

Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives.

Published in:

Molecules, 2014, v. 19, n. 12, p. 20374, doi. 10.3390/molecules191220374

By:

Carvalho, Samir Aquino;
Kaiser, Marcel;
Brun, Reto;
da Silva, Edson Ferreira;
Manssour Fraga, Carlos Alberto

Publication type:

Article

Design, Synthesis and Trypanocidal Evaluation of Novel 1,2,4-Triazoles-3-thiones Derived from Natural Piperine.

Published in:

Molecules, 2013, v. 18, n. 6, p. 6366, doi. 10.3390/molecules18066366

By:

Franklim, Tatiany Nunes;
Freire-de-Lima, Leonardo;
Diniz, Julliana de Nazareth Sá;
Previato, José Osvaldo;
Castro, Rosane Nora;
Mendonça-Previato, Lucia;
de Lima, Marco Edilson Freire

Publication type:

Article

Optimization of signal-to-noise ratio for efficient microarray probe design.

Published in:

Bioinformatics, 2016, v. 32, n. 17, p. i552, doi. 10.1093/bioinformatics/btw451

By:

Matveeva, Olga V.;
Nechipurenko, Yury D.;
Riabenko, Evgeniy;
Ragan, Chikako;
Nazipova, Nafisa N.;
Ogurtsov, Aleksey Y.;
Shabalina, Svetlana A.

Publication type:

Article

An Overview of Pyrazole-Tetrazole-Based Hybrid Compounds: Synthesis Methods, Biological Activities and Energetic Properties.

Published in:

Organics, 2024, v. 5, n. 4, p. 575, doi. 10.3390/org5040030

By:

Cherfi, Mounir;
Harit, Tarik;
Amanchar, Malika;
Oulous, Ahlam;
Malek, Fouad

Publication type:

Article

Structural, molecular hybridization and network based identification of miR-373-3p and miR-520e-3p as regulators of NR4A2 human gene involved in neurodegeneration.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2022, v. 41, n. 5/6, p. 419, doi. 10.1080/15257770.2022.2048851

By:

Singh, Jitender;
Raina, Ashvinder;
Sangwan, Namrata;
Chauhan, Arushi;
Avti, Pramod K

Publication type:

Article

Synthesis and antileishmanial activity of naphthoquinone-based hybrids.

Published in:

Revista Colombiana de Ciencias Químico-Farmacéuticas, 2021, v. 50, n. 2, p. 505, doi. 10.15446/rcciquifa.v50n2.92861

By:

Galvão Guimarães, Délis;
Silva Simplício, Sidney;
Carlos de Sousa, Valéria;
da Franca Rodrigues, Klinger Antonio;
Carvalho, Fernando Aércio A.;
Carneiro, Sabrina M. P.;
Pinheiro da Costa, Marcília;
de A. Gonsalves, Arlan;
Araújo, Cleônia Roberta M.

Publication type:

Article

Electrochemiluminescence Determination of a Specific Sequence of the BCR/ABL Gene Related to Chronic Myelogenous Leukemia with a Ferrocene-Labelled Molecular Beacon and a Gold Nanoparticle (AuNP)-Luminol-Silica Nanocomposite.

Published in:

Analytical Letters, 2022, v. 55, n. 2, p. 203, doi. 10.1080/00032719.2021.1921785

By:

Li, Yue;
Ding, Zhifang;
Bao, Ying;
Han, Kexin;
Li, Guixin

Publication type:

Article

Discovery of 3-(1-Amino-2-phenoxyethylidene)-6-methyl-2 H -pyran-2,4(3 H)-dione Derivatives as Novel Herbicidal Leads.

Published in:

Agronomy, 2023, v. 13, n. 1, p. 202, doi. 10.3390/agronomy13010202

By:

Wang, Chao-Chao;
Chen, Ke;
Li, Na;
Wang, Xue-Kun;
Wang, Shi-Ben;
Li, Pan;
Hua, Xue-Wen;
Lei, Kang;
Ji, Lu-Sha

Publication type:

Article

Gene Expression and miRNA Regulation Changes in Leaves of Rice Backcross Introgression Lines.

Published in:

Agronomy, 2020, v. 10, n. 9, p. 1381, doi. 10.3390/agronomy10091381

By:

Cao, Aqin;
Wang, Ruihua;
Wang, Jianbo

Publication type:

Article

Identification of Copy Number Aberrations in Breast Cancer Subtypes Using Persistence Topology.

Published in:

Microarrays (2076-3905), 2015, v. 4, n. 3, p. 339, doi. 10.3390/microarrays4030339

By:

Arsuaga, Javier;
Borrman, Tyler;
Cavalcante, Raymond;
Gonzalez, Georgina;
Park, Catherine

Publication type:

Article

Synthesis and Biological Evaluation of Coumarin-Linked 4-Anilinomethyl-1,2,3-Triazoles as Potent Inhibitors of Carbonic Anhydrases IX and XIII Involved in Tumorigenesis.

Published in:

Metabolites (2218-1989), 2021, v. 11, n. 4, p. 225, doi. 10.3390/metabo11040225

By:

Thacker, Pavitra S.;
Tiwari, Prerna L.;
Angeli, Andrea;
Srikanth, Danaboina;
Swain, Baijayantimala;
Arifuddin, Mohammed;
Supuran, Claudiu T.

Publication type:

Article

Molecular hybridization modification improves the stability and immunomodulatory activity of TP5 peptide.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1472839

By:

Wang, Junyong;
Tang, Yuan;
Zhao, Xuelian;
Ding, Zetao;
Ahmat, Marhaba;
Si, Dayong;
Zhang, Rijun;
Wei, Xubiao

Publication type:

Article

Stable DNA Sequence Over Close-Ending and Pairing Sequences Constraint.

Published in:

Frontiers in Genetics, 2021, v. 11, p. N.PAG, doi. 10.3389/fgene.2021.644484

By:

Li, Xue;
Wei, Ziqi;
Wang, Bin;
Song, Tao

Publication type:

Article

Hybrids of the Benzofuran Core from Natural Products and the 2,4-Dihydroxy-5-isopropylbenzene Fragment as Potent Hsp90 Inhibitors: Design, Synthesis and Bioevaluation.

Published in:

Molecular Informatics, 2014, v. 33, n. 8, p. 495, doi. 10.1002/minf.201300182

By:

Jia, Jian‐Min;
Liu, Fang;
Xu, Xiao‐Li;
Guo, Xiao‐Ke;
Jiang, Fen;
Huang, Hao‐Zhe;
Pan, Yang;
Cherfaoui, Bahidja;
Sun, Hao‐Peng;
You, Qi‐Dong

Publication type:

Article

Development of a non-radioactive molecular hybridization probe for detecting Strawberry mottle virus in strawberry.

Published in:

Agriscientia, 2016, v. 33, n. 1, p. 39

By:

Asinari, F.;
Cafrune, E. E.;
Guzmán, F. A.;
Conci, L. R.;
Conci, V. C.

Publication type:

Article

Synthesis of N'-(Quinazolin-4-yl)isonicotinohydrazides and their biological screening, docking and ADME studies.

Published in:

Arabian Journal of Chemistry, 2020, v. 13, n. 1, p. 1986, doi. 10.1016/j.arabjc.2018.02.017

By:

Patel, Kinjal D.;
Vekariya, Rajesh H.;
Prajapati, Neelam P.;
Patel, Dhaval B.;
Patel, Hitesh D.;
Shaikh, Tauhid;
Rajani, Dhanji P.;
Rajani, Smita;
Shah, Naumita S.;
Jhala, Devendrasinh

Publication type:

Article

Synthesis and biological evaluation of novel coumarin-chalcone derivatives containing urea moiety as potential anticancer agents.

Published in:

Arabian Journal of Chemistry, 2020, v. 13, n. 1, p. 1120, doi. 10.1016/j.arabjc.2017.10.001

By:

Kurt, Belma Zengin;
Ozten Kandas, Nur;
Dag, Aydan;
Sonmez, Fatih;
Kucukislamoglu, Mustafa

Publication type:

Article

Triazole hybrids as new type of anti-fungal agents.

Published in:

Arabian Journal of Chemistry, 2017, v. 10, n. 3, p. 295, doi. 10.1016/j.arabjc.2013.09.005

By:

Miniyar, Pankaj B.;
Mahajan, Anand A.;
Mokale, Santosh N.;
Shah, Mauli U.;
Kumar, Ashish S.;
Chaturbhuj, Ganesh U.

Publication type:

Article

Multicomponent synthetic strategies and perspectives for synthesis of linked or fused coumarin heterocycles.

Published in:

Journal of the Iranian Chemical Society, 2022, v. 19, n. 10, p. 4035, doi. 10.1007/s13738-022-02603-x

By:

Pasricha, Sharda;
Mittal, Kavita;
Gahlot, Pragya;
Kaur, Harsimar;
Avasthi, Nishita;
Shweta

Publication type:

Article

Exploiting Enantiopure β‐Amino Boronic Acids in Isocyanide‐Based Multicomponent Reactions.

Published in:

European Journal of Organic Chemistry, 2022, v. 2022, n. 25, p. 1, doi. 10.1002/ejoc.202200435

By:

Manenti, Marco;
Gusmini, Simone;
Lo Presti, Leonardo;
Silvani, Alessandra

Publication type:

Article

Multiarmed DNA jumper and metal-organic frameworks–functionalized paper-based bioplatform for small extracellular vesicle–derived miRNAs assay.

Published in:

Journal of Nanobiotechnology, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12951-024-02546-w

By:

Qiu, Xiaopei;
Yang, Huisi;
Shen, Man;
Xu, Hanqing;
Wang, Yingran;
Liu, Shuai;
Liu, Qian;
Sun, Minghui;
Ding, Zishan;
Zhang, Ligai;
Wang, Jun;
Liang, Taotao;
Luo, Dan;
Gao, Mingxuan;
Chen, Ming;
Bao, Jing

Publication type:

Article

Hybrid Molecules with Purine and Pyrimidine Derivatives for Antitumor Therapy: News, Perspectives, and Future Directions.

Published in:

Molecules, 2025, v. 30, n. 13, p. 2707, doi. 10.3390/molecules30132707

By:

Iacob, Simona;
Stefan, Claudia-Simona;
Nechita, Aurel;
Matei, Madalina-Nicoleta;
Lisa, Elena-Lacramioara;
Tutunaru, Dana;
Fulga, Iuliu;
Fulga, Ana;
Cristea, Alina-Georgiana;
Dragostin, Oana-Maria

Publication type:

Article

A Review of Natural and Synthetic Chalcones as Anticancer Agents Targeting Topoisomerase Enzymes.

Published in:

Molecules, 2025, v. 30, n. 12, p. 2498, doi. 10.3390/molecules30122498

By:

Toublet, François-Xavier;
Laurent, Aurélie;
Pouget, Christelle

Publication type:

Article

New Benzothiazole–Monoterpenoid Hybrids as Multifunctional Molecules with Potential Applications in Cosmetics.

Published in:

Molecules, 2025, v. 30, n. 3, p. 636, doi. 10.3390/molecules30030636

By:

Kirkova, Desislava;
Stremski, Yordan;
Bachvarova, Maria;
Todorova, Mina;
Goranov, Bogdan;
Statkova-Abeghe, Stela;
Docheva, Margarita

Publication type:

Article

Novel Antibacterial 4-Piperazinylquinoline Hybrid Derivatives Against Staphylococcus aureus : Design, Synthesis, and In Vitro and In Silico Insights.

Published in:

Molecules, 2025, v. 30, n. 1, p. 28, doi. 10.3390/molecules30010028

By:

La Monica, Gabriele;
Gallo, Annamaria;
Bono, Alessia;
Alamia, Federica;
Lauria, Antonino;
Alduina, Rosa;
Martorana, Annamaria

Publication type:

Article

Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment.

Published in:

Molecules, 2024, v. 29, n. 22, p. 5403, doi. 10.3390/molecules29225403

By:

Navacchia, Maria Luisa;
Cinti, Caterina;
Marchesi, Elena;
Perrone, Daniela

Publication type:

Article

Naturally Inspired Coumarin Derivatives in Alzheimer's Disease Drug Discovery: Latest Advances and Current Challenges.

Published in:

Molecules, 2024, v. 29, n. 15, p. 3514, doi. 10.3390/molecules29153514

By:

Orioli, Rebecca;
Belluti, Federica;
Gobbi, Silvia;
Rampa, Angela;
Bisi, Alessandra

Publication type:

Article

Modulation of the Antimelanoma Activity Imparted to Artemisinin Hybrids by the Monoterpene Counterpart.

Published in:

Molecules, 2024, v. 29, n. 14, p. 3421, doi. 10.3390/molecules29143421

By:

De Marchi, Elisa;
Filippi, Silvia;
Cesarini, Silvia;
Di Maio, Beatrice;
Bizzarri, Bruno Mattia;
Saladino, Raffaele;
Botta, Lorenzo

Publication type:

Article

Recent Trends in the Synthesis and Bioactivity of Coumarin, Coumarin–Chalcone, and Coumarin–Triazole Molecular Hybrids.

Published in:

Molecules, 2024, v. 29, n. 5, p. 1026, doi. 10.3390/molecules29051026

By:

Rohman, Nur;
Ardiansah, Bayu;
Wukirsari, Tuti;
Judeh, Zaher

Publication type:

Article

Development of Novel Pyrrole Derivatives and Their Cinnamic Hybrids as Dual COX-2/LOX Inhibitors.

Published in:

Molecules, 2023, v. 28, n. 24, p. 7958, doi. 10.3390/molecules28247958

By:

Noti, Viola;
Pontiki, Eleni;
Hadjipavlou-Litina, Dimitra

Publication type:

Article

Molecular Hybridization of Alkaloids Using 1,2,3-Triazole-Based Click Chemistry.

Published in:

Molecules, 2023, v. 28, n. 22, p. 7593, doi. 10.3390/molecules28227593

By:

Buchanan, Devan;
Pham, Ashley M.;
Singh, Sandeep K.;
Panda, Siva S.

Publication type:

Article

Design, Synthesis and Evaluation of Praziquantel Analogues and New Molecular Hybrids as Potential Antimalarial and Anti-Schistosomal Agents.

Published in:

Molecules, 2023, v. 28, n. 13, p. 5184, doi. 10.3390/molecules28135184

By:

Kasago, Freddy Mugisho;
Häberli, Cécile;
Keiser, Jennifer;
Masamba, Wayiza

Publication type:

Article

The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β.

Published in:

Molecules, 2023, v. 28, n. 10, p. 4001, doi. 10.3390/molecules28104001

By:

Di Nanni, Adriana;
Saw, Ran Sing;
Bowden, Gregory D.;
Bidesi, Natasha S. R.;
Bjerregaard-Andersen, Kaare;
Korat, Špela;
Herth, Matthias M.;
Pichler, Bernd J.;
Herfert, Kristina;
Maurer, Andreas

Publication type:

Article