Title

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors.

Authors

Jamil, Waqas; Perveen, Shagufta; Ali Shah, Syed Adnan; Taha, Muhammad; Ismail, Nor Hadiani; Perveen, Shahnaz; Ambreen, Nida; Khan, Khalid M.; Choudhary, Muhammad I.

Abstract

Phenoxyacetohydrazide Schiff base analogs 1–28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 μM), 5 (IC50 = 9.47 ± 0.16 μM), 7 (IC50 = 14.7 ± 0.19 μM), 8 (IC50 = 15.4 ± 1.56 μM), 11 (IC50 = 19.6 ± 0.62 μM), 12 (IC50 = 30.7 ± 1.49 μM), 15 (IC50 = 12.0 ± 0.16 μM), 21 (IC50 = 13.7 ± 0.40 μM) and 22 (IC50 = 22.0 ± 0.14 μM) showed promising β-glucuronidase inhibition activity, better than the standard (D-saccharic acid-1,4-lactone, IC50 = 48.4 ± 1.25 μM).

Subjects

PHENOXYACETIC acid; SCHIFF bases; GLUCURONIDASE; LACTONES; SACCHARIN

Publication

Molecules, 2014, Vol 19, Issue 7, p8788

ISSN

1420-3049

Publication type

Academic Journal

DOI

10.3390/molecules19078788