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- Title
The Effect of Butanolides from Cinnamomum tenuifolium on Platelet Aggregation.
- Authors
Huei-Ping Dong; Hui-Ming Wu; Sheue-Jiun Chen; Chung-Yi Chen
- Abstract
This study investigated the effects of isotenuifolide and tenuifolide B from the stems of Cinnamomum tenuifolium on adenosine diphosphate (ADP)-induced human platelet aggregation. Treatment of human platelet-rich plasma with isotenuifolide (1 and 2 μg/μL) and tenuifolide B (1, 2 and 4 μg/μL) did not have any significant effect on human platelet aggregation in vitro, however, treatment of human platelet-rich plasma with isotenuifolide (4 μg/μL) resulted in an inhibitory effect on platelet aggregation, suggesting the potential of this compound as an anti-atherosclerogenic agent in humans. Isotenuifolide is a new butanolide compound, whose structure was characterized by spectral analyses.
- Publication
Molecules, 2013, Vol 18, Issue 10, p11836
- ISSN
1420-3049
- Publication type
Academic Journal
- DOI
10.3390/molecules181011836