Title

New Quinoxaline Derivatives as Potential MT<sub>1</sub> and MT<sub>2</sub> Receptor Ligands.

Authors

Ancizu, Saioa; Castrillo, Nerea; Pérez-Silanes, Silvia; Aldana, Ignacio; Monge, Antonio; Delagrange, Philippe; Caignard, Daniel-Henry; Galiano, Silvia

Abstract

Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands.

Subjects

QUINOXALINES; LIGANDS (Biochemistry); MELATONIN; SLEEP disorders; DRUG receptors; METHOXY group

Publication

Molecules, 2012, Vol 17, Issue 7, p7737

ISSN

1420-3049

Publication type

Academic Journal

DOI

10.3390/molecules17077737