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- Title
Synthesis and Biological Evaluation of Novel Benzothiazole-2-thiol Derivatives as Potential Anticancer Agents.
- Authors
Xuan-Hong Shi; Zhao Wang; Yong Xia; Ting-Hong Ye; Mei Deng; You-Zhi Xu; Yu-Quan Wei; Luo-Ting Yu
- Abstract
A series of novel benzothiazole-2-thiol derivatives were synthesized and their structures determined by 1H-NMR, 13C-NMR and HRMS (ESI). The effects of all compounds on a panel of different types of human cancer cell lines were investigated. Among them, pyridinyl-2-amine linked benzothiazole-2-thiol compounds 7d, 7e, 7f and 7i exhibited potent and broad-spectrum inhibitory activities. Compound 7e displayed the most potent anticancer activity on SKRB-3 (IC50 = 1.2 nM), SW620 (IC50 = 4.3 nM), A549 (IC50 = 44 nM) and HepG2 (IC50 = 48 nM) and was found to induce apoptosis in HepG2 cancer cells.
- Publication
Molecules, 2012, Vol 17, Issue 4, p3933
- ISSN
1420-3049
- Publication type
Academic Journal
- DOI
10.3390/molecules17043933