Title

New Phenol Derivatives from the Haima Cold Seep-Derived Fungus Aspergillus subversicolor CYH-17.

Authors

Che, Yi-Hao; Ding, Wen-Ping; Xiao, Zhi-Hui; Wu, Jia-Min; Yin, Hao; Wang, Fa-Zuo; Zhang, Si

Abstract

Seven new phenol derivatives, subversins A–E (1–5), subversic acid A (6) and epi-wortmannine G (7); one new natural product, 4-hydroxy-7-methoxyphthalide (8); and five known compounds (9–13) were isolated from the fungus Aspergillus subversicolor CYH-17 collected from the Haima cold seep. The structures and absolute configurations of these compounds were determined via NMR, MS, optical rotation, electronic circular dichroism (ECD) calculation, X-ray diffraction analysis and comparison with the literature. Compounds 2 and 5 were two pairs of enantiomers. All compounds were tested for their α-glucosidase and acetylcholinesterase (AChE) inhibitory activity, antioxidant activity and antibacterial activity, but no obvious activity was observed among these studied compounds.

Subjects

COLD seeps; ASPERGILLUS; OPTICAL rotation; CIRCULAR dichroism; ANTIBACTERIAL agents

Publication

Marine Drugs, 2024, Vol 22, Issue 3, p117

ISSN

1660-3397

Publication type

Academic Journal

DOI

10.3390/md22030117