Title

Sirtuins: Emergent Players in Tissue and Organ Regeneration.

Authors

Núñez, Ayla Kyler; Arenas-Gómez, Claudia Marcela; Carbonell Medina, Belfran Alcides

Abstract

Sirtuins are a family of lysine deacetylases that regulate cellular homeostasis and energy sensing. Regeneration is the process that restores structural and functional homeostasis at the cellular, tissue, organ, and appendage levels. Several cellular processes, such as epithelial–mesenchymal transition (EMT), proliferation, migration, and differentiation, contribute to restoration after an injury. This review highlights the role of sirtuins in tissue, organ, and anatomical structure regeneration, showing how sirtuins modulate signalling pathways by deacetylating targets such as transcription factors. Furthermore, understanding the role of this protein family could help elucidate the molecular and cellular mechanisms underlying tissue regeneration, which may hold significant potential for fields such as regenerative medicine. The review compiles evidence suggesting that sirtuins are emerging factors in the regeneration of various organs (e.g., skin, liver, heart) and tissues (e.g., bone, muscle, cornea, spinal cord).

Subjects

SIRTUINS; ORGANISTS; CELLULAR signal transduction; REGENERATIVE medicine; SPINAL cord

Publication

International Journal of Translational Medicine, 2024, Vol 4, Issue 4, p687

ISSN

2673-8937

Publication type

Academic Journal

DOI

10.3390/ijtm4040048