Title

Recent Advances in the Use of Vitamin D Organic Nanocarriers for Drug Delivery.

Authors

Aggeletopoulou, Ioanna; Kalafateli, Maria; Geramoutsos, Georgios; Triantos, Christos

Abstract

Nanotechnology, now established as a transformative technology, has revolutionized medicine by enabling highly targeted drug delivery. The use of organic nanocarriers in drug delivery systems significantly enhances the bioavailability of vitamins and their analogs, thereby improving cellular delivery and therapeutic effects. Vitamin D, known for its crucial role in bone health, also influences various metabolic functions, such as cellular proliferation, differentiation, and immunomodulation, and is increasingly explored for its anticancer potential. Given its versatile properties and biocompatibility, vitamin D is an attractive candidate for encapsulation within drug delivery systems. This review provides a comprehensive overview of vitamin D synthesis, metabolism, and signaling, as well as its applications in customized drug delivery. Moreover, it examines the design and engineering of organic nanocarriers that incorporate vitamin D and discusses advances in this field, including the synergistic effects achieved through the combination of vitamin D with other therapeutic agents. By highlighting these innovations, this review provides valuable insights into the development of advanced drug delivery systems and their potential to enhance therapeutic outcomes.

Subjects

TARGETED drug delivery; BONE health; VITAMIN D; TREATMENT effectiveness; CELL proliferation; DRUG delivery systems

Publication

Biomolecules (2218-273X), 2024, Vol 14, Issue 9, p1090

ISSN

2218-273X

Publication type

Academic Journal

DOI

10.3390/biom14091090