Title

Propyl Gallate.

Authors

Nguyen, Van Hai; Le, Minh Ngoc; Nguyen, Hoa Binh; Ha, Kieu Oanh; Pham, Thai Ha Van; Nguyen, Thi Hong; Dao, Nguyet Suong Huyen; Nguyen, Van Giang; Nguyen, Dinh Luyen; Trinh, Nguyen Trieu

Abstract

The title compound, propyl gallate (III), is an important substance popularly used in the food, cosmetic and pharmaceutical industries. Current chemical syntheses of this compound are based on the acylation supported by thionyl chloride, DIC/DMAP or Fischer esterification using a range of homogenous and heterogenous catalysts. In this paper, an efficient, green, straightforward, and economical method for synthesizing propyl gallate using potassium hydrogen sulfate, KHSO4, as the heterogenous acidic catalyst has been developed for the first time. In addition, this paper provides a comprehensive spectral dataset for the title compound, especially the new data on DEPT and 2D NMR (HSQC and HMBC) spectra which are not currently available in the literature.

Subjects

SULFURIC acid; POTASSIUM sulfate; CHEMICAL synthesis; THIONYL chloride; SUBSTANCE abuse; CATALYSTS; ACYLATION

Publication

Molbank, 2021, Vol 2021, Issue 2, pM1201

ISSN

1422-8599

Publication type

Academic Journal

DOI

10.3390/M1201