Works matching DE "TUMOR microenvironment"

Results: 5000

Innovative immunotherapeutic strategies for gastric cancer: A comprehensive review.

Published in:

AIMS Allergy & Immunology, 2025, v. 9, n. 1, p. 1

By:

Sheikh, Mujibullah;
Jirvankar, Pranita S.

Publication type:

Article

Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1579184

By:

Du, Haiyang;
Si, Gao;
Si, Jiqing;
Song, Xuejie;
Si, Fuchun

Publication type:

Article

Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1506204

By:

Ogawa, Hisataka;
Ekawa, Tomoya;
Mizote, Yu;
Akazawa, Takashi;
Tahara, Hideaki

Publication type:

Article

Mechanistic Aspects of Inflammation and Oxidative Stress and Their Association With Thyroid Cancer Risk.

Published in:

Cancer Medicine, 2025, v. 14, n. 13, p. 1, doi. 10.1002/cam4.71030

By:

Zhang, Bo‐Tao;
Guo, Mao;
Yang, Liu‐Rui;
Zeng, Yang;
Jiang, Jun

Publication type:

Article

Tumor‐Infiltrating Lymphocytes in Breast and Female Genital Tract Cancers: Overlooked Potential and Unexplored Frontiers.

Published in:

Cancer Medicine, 2025, v. 14, n. 13, p. 1, doi. 10.1002/cam4.71023

By:

Skok, Kristijan;
Maccio, Umberto;
Martin, Spencer D.;
Bräutigam, Konstantin

Publication type:

Article

RXRG as a Novel Biomarker and its Correlation With Immune Infiltration in Thyroid Carcinoma.

Published in:

In Vivo, 2025, v. 39, n. 4, p. 2013, doi. 10.21873/invivo.13998

By:

PENGZHAO SONG;
TIANQI CHEN;
PENGFEI GU;
YAHUI SUN;
YONG HAN

Publication type:

Article

Single-cell RNA sequencing reveals the effects of mental stress on mouse mammary tumors and the tumor microenvironment.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02619-1

By:

Liu, Pengfei;
Ma, Wenjing;
Wang, Tao;
Lü, Jinhui;
Wang, Weizhong;
Wang, Yixing;
Tang, Qifan;
Di, Jing;
Bischof, Evelyne;
Zhao, Qian;
Yu, Zuoren

Publication type:

Article

AI-powered prediction model for neoadjuvant chemotherapy efficacy: comprehensive analysis of breast cancer histological images.

Published in:

NPJ Precision Oncology, 2025, v. 9, n. 1, p. 1, doi. 10.1038/s41698-025-01033-1

By:

Li, Fengling;
Wei, Yani;
Zhang, Wenchuan;
Zhao, Yuanyuan;
Fu, Jing;
Xiao, Xiuli;
Qiu, Yan;
Yi, Yuhao;
Yang, Yongquan;
Bu, Hong

Publication type:

Article

Deciphering cancer therapy resistance via patient-level single-cell transcriptomics with CellResDB.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-08457-2

By:

Liu, Tianyuan;
Qiao, Huiyuan;
Ren, Liping;
Ye, Xiucai;
Zou, Quan;
Zhang, Yang

Publication type:

Article

High-resolution mapping of single cells in spatial context.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61667-4

By:

Ke, Jincan;
Xu, Jian;
Liu, Jia;
Yang, Yumeng;
Guo, Chenkai;
Xie, Bingbing;
Cui, Guizhong;
Peng, Guangdun;
Suo, Shengbao

Publication type:

Article

Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-61434-5

By:

Liu, Yanyan;
Wang, Qikai;
Feng, Zhenhan;
Qin, Mengmeng;
Zhang, Zhenyu;
Jiang, Jinhong;
Ren, Tongxiang;
Liu, Xiangsheng;
Jeffrey Brinker, C.;
Zhao, Yuliang;
Meng, Huan

Publication type:

Article

Global research trends in tryptophan metabolism and cancer: a bibliometric and visualization analysis (2005–2024).

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1621666

By:

Ma, Huanhuan;
Ding, Ran;
Wang, Junwen;
Du, Guangying;
Zhang, Yun;
Lu, Qiuchen;
Hou, Yingyue;
Chen, Haosong;
Jiao, Hongguan

Publication type:

Article

SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinoma.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1606195

By:

Xu, Wei-Xuan;
Ye, Ya-Mei;
Chen, Jia-Lin;
Guo, Xin-Ying;
Li, Chen;
Luo, Juan;
Lu, Lin-Bin;
Chen, Xiong

Publication type:

Article

Immunosenescence-Related Gene MAFF is Involved in Immune Regulation and Malignant Progression in Pancreatic Adenocarcinoma.

Published in:

Biological Procedures Online, 2025, v. 27, n. 1, p. 1, doi. 10.1186/s12575-025-00278-1

By:

Zhang, Fenglin;
Liu, Kexin;
Ao, Mengfan;
Zhao, Jiangang;
Liao, Xinghe;
Li, Ping;
Chen, Hao

Publication type:

Article

Developing angiogenesis-related prognostic biomarkers and therapeutic strategies in bladder cancer using deep learning and machine learning.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-08945-9

By:

Li, Yutong;
Zuo, Ling;
Song, Xingyu;
Huang, Yuyang;
Zou, Ke;
Dong, Xuan;
Liu, Hongwei

Publication type:

Article

Bioinformatics analysis of COMMD family in pan-cancer reveals potential biomarkers and therapeutic targets.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-11118-3

By:

Wang, Sihan;
Cheng, Jinglei;
Hu, Zhiya;
Zhao, Hongjun;
Ye, Lifen;
Li, Jingyong;
Deng, Youyuan;
He, Ye

Publication type:

Article

A novel cancer-associated membrane signature predicts prognosis and therapeutic response for lung adenocarcinoma.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-11105-8

By:

Tu, Biao;
Wu, Jun;
Zhang, Wei;
Tang, Haitao;
Dai, Tenghui;
Xie, Bingfeng

Publication type:

Article

TNFAIP2 deficiency drives formation of an immunosuppressive tumor microenvironment and confers resistance to anti-PD-1 therapy in skin cutaneous melanoma.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10952-9

By:

Wang, Yaning;
Wang, Jinsong;
Chen, Zhihong;
Zhong, Chiyang;
Luo, Hao;
Xu, Teng

Publication type:

Article

MTAP deficiency is highly homogeneous in advanced, muscle-invasive urothelial carcinoma of the urinary bladder.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10157-0

By:

Gorbokon, Natalia;
Teljuk, Katharina;
Reiswich, Viktor;
Lutz, Florian;
Rico, Sebastian Dwertmann;
Lühr, Clara;
Bernreuther, Christian;
Al Bunni, Yaryna Klos;
Völkel, Cosima;
Plage, Henning;
Lennartz, Maximilian;
Fisch, Margit;
Minner, Sarah;
Simon, Ronald;
Sauter, Guido;
Zecha, Henrik;
Steurer, Stefan;
Schlomm, Thorsten;
Vlajnic, Tatjana;
Bubendorf, Lukas

Publication type:

Article

Integrating bulk and single-cell RNA sequencing reveals intratumor heterogeneity phenotypes and immune infiltration in pancreatic cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03080-3

By:

Zhao, Li;
Huang, Yao;
Li, Jiang;
Xie, Rui;
Li, Kaiming

Publication type:

Article

Genetic determinants of head and neck cancer: exploring causality among immune cells and plasma metabolites through two-sample Mendelian randomization and mediation analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03181-z

By:

Lu, Yuting;
Du, Xiangnan;
Liu, Hanlin;
He, Qing;
Cao, Xiaolin

Publication type:

Article

Mechanism of crosstalk between Helicobacter pylori and immune stromal cells in the development and occurrence of gastric cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03163-1

By:

Wu, Yang;
Zhang, Runbing;
Li, Tian;
Zhang, Jiucong;
Yu, Xiaohui;
Zheng, Xiaofeng

Publication type:

Article

SLC3A2 as a key anoikis−related gene for prognosis and tumor microenvironment remodeling in melanoma.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03125-7

By:

Liu, Xiaojin;
Xie, Jiaheng;
Xiao, Yingying

Publication type:

Article

SPDL1 overexpression was associated with poor prognosis and immune status in HCC through in vitro experiment and bioinformatics analysis.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-03089-8

By:

Xu, Ying-Ming;
You, Bo-Hua;
Chen, Ming;
Xiong, Tian-Ping;
Shi, Lin;
Wei, Qin;
Wang, Zhong-An

Publication type:

Article

Zwilch kinetochore protein affects the prognosis of cancer patients by participating in cell proliferation, enhancing cell communication, and reshaping the tumor microenvironment.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02981-7

By:

Yao, Long;
Liu, Lianpo;
Wu, Jinsong;
Huang, Yunlong;
Zhang, Renquan;
Zhang, Haoxue

Publication type:

Article

Hypoxia- and lactate metabolism-associated prognostic and therapeutic signature in pancreatic cancer.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02873-w

By:

Zhang, Chen-Hui;
Huang, An-Qi;
Shi, Cang-Chang;
Jiang, Zhi-Jia;
Yao, Hao;
Sun, Jin-Jin

Publication type:

Article

Exploring the potential value of SRC in pan cancer based on bioinformatics methods.

Published in:

Discover Oncology, 2025, v. 16, n. 1, p. 1, doi. 10.1007/s12672-025-02402-9

By:

Huang, Liyin;
Lu, Yanwen;
Yi, Lei;
Zhao, Yuxin;
Si, Tao;
Zhang, Mingmin

Publication type:

Article

Deep learning-based tumor segmentation and radiogenomic model for predicting EGFR amplification and assessing intratumoural heterogeneity in glioblastoma.

Published in:

Journal of Big Data, 2025, v. 12, n. 1, p. 1, doi. 10.1186/s40537-025-01221-7

By:

Liu, Jianpeng;
Shen, Chuyun;
Jiang, Shufan;
Wu, Yanfei;
Tu, Jiaqi;
Bao, Yifang;
Li, Haiqing;
Wang, Na;
Liu, Ying;
Xiong, Ji;
Liu, Xueling;
Li, Yuxin

Publication type:

Article

Recent research advances in interleukin, microRNA and neuroendocrine tumor biomarkers (Review).

Published in:

Molecular & Clinical Oncology, 2025, v. 23, n. 2, p. N.PAG, doi. 10.3892/mco.2025.2866

By:

Guo, Xiaofan;
Yang, Shaofeng;
Cao, Chunli;
Li, Donghai

Publication type:

Article

T cells in cancer: mechanistic insights and therapeutic advances.

Published in:

Biomarker Research, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40364-025-00807-w

By:

Pu, Jingjing;
Liu, Ting;
Zhou, Yi;
Chen, Mengping;
Fu, Xuehang;
Wan, Yike;
Wang, Junying;
Chen, Binzhen;
Sharma, Amit;
Lukacs-Kornek, Veronika;
Schmidt-Wolf, Ingo G.H.;
Hou, Jian

Publication type:

Article

Integrated genomics with refined cell-of-origin subtyping distinguishes subtype-specific mechanisms of treatment resistance and relapse in diffuse large B-cell lymphoma.

Published in:

Blood Cancer Journal, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41408-025-01326-5

By:

Walker, Janek S.;
Wenzl, Kerstin;
Novak, Joseph P.;
Stokes, Matthew E.;
Hopper, Melissa A.;
Dropik, Abigail R.;
Siminski, Miranda S.;
Bock, Allison M.;
Sarangi, Vivekananda;
Ortiz, Maria;
Stong, Nicholas;
Huang, C. Chris;
Maurer, Matthew J.;
Link, Brian K.;
Ansell, Stephen M.;
Habermann, Thomas M.;
Witzig, Thomas E.;
King, Rebecca L.;
Nowakowski, Grzegorz;
Cerhan, James R.

Publication type:

Article

TMEM150A overexpression was associated with poor prognosis and cancer progression in glioma verified by comprehensive analysis and cell experiments.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-08752-2

By:

Xu, Hao-Qiang;
Zhao, Dan;
Xu, Shi-Hao;
Mao, Rui;
Yang, Wen-Qiong;
Han, Qi

Publication type:

Article

Comprehensive analysis of Mendelian randomization and scRNA-seq identify key prognostic genes and relevant functional roles in colorectal cancer.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10354-x

By:

Hu, Meng;
Dong, Haotian;
Chen, Chujia;
Ye, Chengyuan;
Yan, Jianing;
Yu, Xuan;
Ye, Guoliang;
Shao, Yongfu

Publication type:

Article

Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-10290-w

By:

Cao, Qianqian;
Zhang, Yuzhe;
Cheng, Cheng;
Wang, Xiaoyang;
Fan, Panlong;
Huang, Jincheng;
Dai, Zhipeng

Publication type:

Article

Characterization of lysine crotonylation-related lncRNAs for prognostic assessment and immune response in glioma.

Published in:

Frontiers in Pharmacology, 2025, p. 1, doi. 10.3389/fphar.2025.1573694

By:

Song, Miaomiao;
Xu, Juan;
Gui, Zhonghao;
Wu, Yun;
Wang, Feifei;
Sheng, Hongmei;
Huang, Xueyong;
Qian, Junyu;
Qin, Haotian;
Wang, Ying

Publication type:

Article

Editorial: Mitochondrial damage interacts with the immune system and tumor microenvironment.

Published in:

2025

By:

Lin, Xundong;
Yuan, Xin;
Luo, Yiheng;
Fang, Haihong;
Guo, Weihong

Publication type:

Editorial

Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer.

Published in:

Functional & Integrative Genomics, 2025, v. 25, n. 1, p. 1, doi. 10.1007/s10142-025-01660-8

By:

Gao, Yanqing;
Bao, Shuguang;
Wen, Bao;
Li, Haoyuan;
Guo, Qiang;
Li, Ao;
Bao, Luri;
Li, Meitao;
Han, Bateer

Publication type:

Article

Retrospective study on the correlation between CXCL13, immune infiltration, and tertiary lymphoid structures in cutaneous squamous cell carcinoma.

Published in:

PeerJ, 2025, p. 1, doi. 10.7717/peerj.19398

By:

Chen, Yulu;
Wu, Yuhao;
Zhao, Zijun;
Wen, Long;
Wu, Mingshun;
Song, Dekun;
Zeng, Qingyu;
Liu, Yeqiang;
Yan, Guorong;
Zhang, Guolong

Publication type:

Article

Metabolic reprogramming in colorectal cancer: a review of aerobic glycolysis and its therapeutic implications for targeted treatment strategies.

Published in:

Cell Death Discovery, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41420-025-02623-5

By:

Pang, Boran;
Wu, Hao

Publication type:

Article

Ultrasound‐Responsive Lipid Nanosonosensitizers with Size Reduction and NO Release: Synergistic Sonodynamic‐Chemo‐Immunotherapy for Pancreatic Tumors.

Published in:

Angewandte Chemie, 2025, v. 137, n. 29, p. 1, doi. 10.1002/ange.202507388

By:

Fang, Leyi;
Zeng, Wenhui;
Liu, Yili;
Miao, Yinxing;
Lu, Chunmei;
Xu, Zhonghan;
Zhou, Sensen;
Xue, Qi;
Xu, Yitong;
Jiang, Xiqun;
Xu, Jingjuan;
Zhang, Yan;
Ye, Deju

Publication type:

Article

Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia development.

Published in:

Molecular Cancer, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12943-025-02379-7

By:

Chen, Guoming;
Chen, Bonan;
Wu, Yilin;
Nie, Hao;
Zhong, Zilan;
Yang, Shuyang;
Qin, Rui;
Kang, Wei;
Zhang, Cheng;
Wang, Ning;
Feng, Yibin

Publication type:

Article

Losartan as a mechanotherapeutic adjuvant: Remodeling the breast tumor microenvironment to improve treatment efficacy.

Published in:

PLoS ONE, 2025, v. 20, n. 7, p. 1, doi. 10.1371/journal.pone.0328196

By:

Dwairy, Mutaz;
Yehya, Alaa;
Mohammad, Feras M.;
Alzoubi, Hiba

Publication type:

Article

PTX3 调节胶质瘤TMZ耐药的研究进展.

Published in:

Journal of Clinical Neurosurgery / Linchuang Shenjingwaike Zazhi, 2025, v. 22, n. 3, p. 330, doi. 10.3969/j.issn.167-7770.202503.016

By:

李阳洋;
金朝晖;
汤磊;
王冉;
杨坤

Publication type:

Article

DECEPTICON: a correlation-based strategy for RNA-seq deconvolution inspired by a variation of the Anna Karenina principle Open Access.

Published in:

Briefings in Bioinformatics, 2025, v. 26, n. 3, p. 1, doi. 10.1093/bib/bbaf234

By:

Deng, Fulan;
Zou, Jiawei;
Wang, Miaochen;
Gu, Yida;
Wu, Jiale;
Gao, Lianchong;
Ji, Yuan;
Tong, Henry H Y;
Chen, Jie;
Chen, Wantao;
Tan, Lianjiang;
Chu, Yaoqing;
Zou, Xin;
Hao, Jie

Publication type:

Article

Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview.

Published in:

Molecules, 2025, v. 30, n. 13, p. 2792, doi. 10.3390/molecules30132792

By:

Wang, Wang;
Zhou, Hanting;
Sen, Akanksha;
Zhang, Pengxia;
Yuan, Linhong;
Zhou, Shaobo

Publication type:

Article

敲低 PTGS2 抑制肿瘤相关巨噬细胞M2极化在鼻咽癌治疗中的应用价值.

Published in:

Journal of China Medical University, 2025, v. 54, n. 7, p. 613, doi. 10.12007/j.issn.0258‐4646.2025.07.007

By:

姚晨;
黄鑫;
李钢;
李增沛;
李征

Publication type:

Article

Integrative Multi-Omics Analysis Reveals the Molecular Characteristics, Tumor Microenvironment, and Clinical Significance of Ubiquitination Mechanisms in Lung Adenocarcinoma.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6501, doi. 10.3390/ijms26136501

By:

Long, Deyu;
Xue, Yajing;
Yu, Xiushi;
Qin, Xue;
Chen, Jiaxin;
Luo, Jia;
Ma, Ketao;
Wei, Lili;
Li, Xinzhi

Publication type:

Article

Effects of the Alkylating Agent Cyclophosphamide in Potentiating Anti-Tumor Immunity.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6440, doi. 10.3390/ijms26136440

By:

Gephart, Benjamin D.;
Coulter, Don W.;
Solheim, Joyce C.

Publication type:

Article

Biomimetic Tumour Model Systems for Pancreatic Ductal Adenocarcinoma in Relation to Photodynamic Therapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6388, doi. 10.3390/ijms26136388

By:

Smith, Olivia M.;
Lintern, Nicole;
Tian, Jiahao;
Mesquita, Bárbara M.;
Oliveira, Sabrina;
Vymetalkova, Veronika;
Prakash, Jai;
Smith, Andrew M.;
Jayne, David G.;
Heger, Michal;
Khaled, Yazan S.

Publication type:

Article

Shifting Shapes: The Endothelial-to-Mesenchymal Transition as a Driver for Cancer Progression.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6353, doi. 10.3390/ijms26136353

By:

Giordanengo, Lucia;
Proment, Alessia;
Botta, Virginia;
Picca, Francesca;
Munir, H. M. Waqas;
Tao, Jiahao;
Olivero, Martina;
Taulli, Riccardo;
Bersani, Francesca;
Sangiolo, Dario;
Novello, Silvia;
Scagliotti, Giorgio Vittorio;
Merlini, Alessandra;
Doronzo, Gabriella

Publication type:

Article