Title

The Dark That Matters: Long Non-coding RNAs as Master Regulators of Cellular Metabolism in Non-communicable Diseases.

Authors

Mongelli, Alessia; Martelli, Fabio; Farsetti, Antonella; Gaetano, Carlo

Abstract

Non-coding RNAs are pivotal for many cellular functions, such as splicing, gene regulation, chromosome structure, and hormone-like activity. Here, we will report about the biology and the general molecular mechanisms associated with long non-coding RNAs (lncRNAs), a class of >200 nucleotides-long ribonucleic acid sequences, and their role in chronic non-transmissible diseases. In particular, we will summarize knowledge about some of the best-characterized lncRNAs, such as H19 and MALAT1, and how they regulate carbohydrate and lipid metabolism as well as protein synthesis and degradation. Evidence is discussed about how lncRNAs expression might affect cellular and organismal metabolism and whether their modulation could provide ground for the development of innovative treatments.

Subjects

NON-communicable diseases; NON-coding RNA; CELL metabolism; CHROMOSOME structure; GENETIC regulation

Publication

Frontiers in Physiology, 2019, pN.PAG

ISSN

1664-042X

Publication type

Academic Journal

DOI

10.3389/fphys.2019.00369