Title

HER2-targeted therapies for HER2-positive early-stage breast cancer: present and future.

Authors

Luying Xu; Yuxin Xie; Qiheng Gou; Rui Cai; Rong Bao; Yucheng Huang; Ruisi Tang

Abstract

Breast cancer (BC) has the second highest incidence among cancers and is the leading cause of death among women worldwide. The human epidermal growth factor receptor 2 (HER2) is overexpressed in approximately 20%--30% of BC patients. The development of HER2-targeted drugs, including monoclonal antibodies (mAbs), tyrosine kinase inhibitors (TKIs) and antibody--drug conjugates (ADCs), has improved the operation rate and pathological remission rate and reduced the risk of postoperative recurrence for HER2- positive early-stage BC (HER2+ EBC) patients. This review systematically summarizes the mechanisms, resistance, therapeutic modalities and safety of HER2-targeted drugs and helps us further understand these drugs and their use in clinical practice for patients with HER2+ EBC.

Subjects

HER2 positive breast cancer; PROTEIN-tyrosine kinase inhibitors; BREAST cancer; NEOADJUVANT chemotherapy; CANCER treatment

Publication

Frontiers in Pharmacology, 2024, p01

ISSN

1663-9812

Publication type

Academic Journal

DOI

10.3389/fphar.2024.1446414