Title

Cholesterol metabolism: a positive target to revoke the function of exhausted CAR-NK cells in tumor microenvironment.

Authors

Jingfeng Liu

Abstract

The article explores the relationship between cholesterol metabolism and the tumor immune suppressive microenvironment (TIME), which can hinder the body's immune response to tumors. Cholesterol accumulation has been found to negatively impact the function of natural killer (NK) cells, including CAR-NK cells, which are crucial for fighting tumor cells. The article suggests that targeting cholesterol metabolism could potentially enhance the effectiveness of CAR-NK cells in tumor therapies. However, the article also acknowledges the need for further research to validate these approaches and address potential limitations and side effects.

Subjects

STEROL regulatory element-binding proteins; T-cell exhaustion; KILLER cells; REGULATORY T cells; CELL metabolism; CHOLESTEROL metabolism

Publication

Frontiers in Pharmacology, 2024, p1

ISSN

1663-9812

Publication type

Academic Journal

DOI

10.3389/fphar.2024.1440869