Title

Deconvoluting the Complexity of Reactive Oxygen Species (ROS) in Neurodegenerative Diseases.

Authors

Zhou, Yuxin; Zhen, Yongqi; Wang, Guan; Liu, Bo

Abstract

Neurodegenerative diseases (NDs) are becoming a serious public health concern as the world's population continues to age, demanding the discovery of more effective therapies. Excessive formation of reactive oxygen species (ROS) can result in oxidative stress (OS), which can be regarded as one of the common causes of neurodegenerative diseases (NDs). Thus, in this review, we focus on summarizing the consequences of ROS NDs, while taking the four prevalent NDs as examples, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), to illustrate the key signaling pathways and relevant drugs. Together, these findings may shed new light on a field in which ROS-related pathways play a key role; thereby setting the groundwork for the future therapeutic development of neurodegenerative diseases.

Subjects

REACTIVE oxygen species; NEURODEGENERATION; ALZHEIMER'S disease; AMYOTROPHIC lateral sclerosis; HUNTINGTON disease

Publication

Frontiers in Neuroanatomy, 2022, Vol 16, p1

ISSN

1662-5129

Publication type

Academic Journal

DOI

10.3389/fnana.2022.910427