Title

Editorial: Inborn Errors of Immunity (IEI) breaking immune homeostasis and tolerance: a key role for T regulatory cells.

Authors

De Rosa, Veronica; Sogkas, Georgios; Bacchetta, Rosa

Abstract

The editorial in Frontiers in Immunology discusses Inborn Errors of Immunity (IEI) and their impact on immune homeostasis and tolerance, with a focus on T regulatory cells. IEI are caused by mutations in genes regulating immune processes, leading to susceptibility to infections and immune-related complications. The article highlights the classification of IEI into 9 groups and introduces the concept of Primary Immune Regulatory Disorders (PIRDs) and Tregopathies. It also explores the role of Tregs in various immune disorders and potential therapeutic approaches for IEI.

Subjects

REGULATORY T cells; REGULATORY B cells; IMMUNOLOGIC memory; IMMUNITY; TRANSCRIPTION factors

Publication

Frontiers in Immunology, 2025, p1

ISSN

1664-3224

Publication type

Academic Journal

DOI

10.3389/fimmu.2024.1532079