Your institution may have access to this item. Find your institution then sign in to continue.

Title: Hepatoprotective activity of aqueous aqueous-methanolic extract of Suaeda fruticosa in paracetamol paracetamol-induced hepatotoxicity in rabbits.
Authors: Rehman, Jalil Ur; Saqib, Najam Us; Akhtar, Naveed; Jamshaid, Muhammad; Asif, Hafiz Muhammad; Sultana, Sabira; Rehman, Riaz Ur
Abstract: In the present study, we evaluated the protective effects of the aqueousmethanolic extract of Suaeda fruticosa (500 mg/kg and 750 mg/kg b.w., p.o) against paracetamol-induced hepatotoxicity in rabbits. Silymarin 100 mg/kg, p.o. was served as standard. The degree of protection was determined by measuring the levels of biochemical marker such as SGOT, SGPT, ALP and bilirubin (total). The results showed that extract of S. fruticosa significantly (p<0.05) decreased the paracetamol-induced increased levels of liver enzymes and total bilirubin in a dose dependent manner. Histopathological studies also revealed the hepatoprotective effects of S. fruticosa. It is concluded that the aqueous-methanolic extract of S. fruticosa possesses hepatoprotective activity.
Subjects: HEPATOTOXICOLOGY; ACETAMINOPHEN; LABORATORY rabbits; SILYMARIN; HISTOPATHOLOGY; BIOMARKERS; THERAPEUTICS
Publication: Bangladesh Journal of Pharmacology, 2013, Vol 8, Issue 4, p378
ISSN: 1991-007X
Publication type: Academic Journal
DOI: 10.3329/bjp.v8i4.16631

We found a match

Hepatoprotective activity of aqueous aqueous-methanolic extract of Suaeda fruticosa in paracetamol paracetamol-induced hepatotoxicity in rabbits.