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- Title
Highly activated and expanded natural killer cells for multiple myeloma immunotherapy.
- Authors
Garg, Tarun K; Szmania, Susann M; Khan, Junaid A; Hoering, Antje; Malbrough, Paul A; Moreno-Bost, Amberly; Greenway, Amy D; Lingo, Joshuah D; Li, Xin; Yaccoby, Shmuel; Suva, Larry J; Storrie, Brian; Tricot, Guido; Campana, Dario; Shaughnessy, John D, Jr; Nair, Bijay P; Bellamy, William T; Epstein, Joshua; Barlogie, Bart; van Rhee, Frits
- Abstract
Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma.
- Publication
Haematologica, 2012, Vol 97, Issue 9, p1348
- ISSN
1592-8721
- Publication type
Journal Article
- DOI
10.3324/haematol.2011.056747