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- Title
Marked upregulation of Survivin and Aurora-B kinase is associated with disease progression in the myelodysplastic syndromes.
- Authors
Yoshida, Akira; Zokumasu, Kouichi; Wano, Yuji; Yamauchi, Takahiro; Imamura, Shin; Takagi, Kazutaka; Kishi, Shinji; Urasaki, Yoshimasa; Tohyama, Kaoru; Ueda, Takanori
- Abstract
Myelodysplastic syndromes are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis. Survivin is a member of the inhibitor of apoptosis family and suppresses apoptosis. Survivin also functions as a subunit of the chromosomal passenger complex for regulating mitosis with Aurora-B. Survivin and Aurora-B play an important role in maintaining genome stability. The aim of this study was to determine the role of Survivin and Aurora-B kinase in disease progression and prognosis of myelodysplastic syndromes.
- Publication
Haematologica, 2012, Vol 97, Issue 9, p1372
- ISSN
1592-8721
- Publication type
Journal Article
- DOI
10.3324/haematol.2011.055681