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- Title
Treatment of an autoimmune encephalomyelitis mouse model with nonmyeloablative conditioning and syngeneic bone marrow transplantation.
- Authors
Meng, Li; Ouyang, Jian; Zhang, Haitao; Wen, Yanting; Chen, Junhao; Zhou, Jinyong
- Abstract
Hematopoietic stem cell transplantation (HSCT) has been proposed as a novel therapy for multiple sclerosis (MS). CD4 + CD25 + regulatory T cells (Tregs) expressing Foxp3 play an important role in the maintenance of immune tolerance to self. Our study was conducted to confirm the efficiency of nonmyeloablative conditioning and syngeneic bone marrow transplantation (BMT) on experimental autoimmune encephalomyelitis (EAE) mice and to determine whether Tregs plays a role in the underlying mechanism.
- Publication
Restorative neurology and neuroscience, 2011, Vol 29, Issue 3, p177
- ISSN
1878-3627
- Publication type
Journal Article
- DOI
10.3233/RNN-2011-0590