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- Title
Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years.
- Authors
Zetterberg, Henrik; Pedersen, Mona; Lind, Karin; Svensson, Maria; Rolstad, Sindre; Eckerström, Carl; Syversen, Steinar; Mattsson, Ulla-Britt; Ysander, Christina; Mattsson, Niklas; Nordlund, Arto; Vanderstichele, Hugo; Vanmechelen, Eugeen; Jonsson, Michael; Edman, Ake; Blennow, Kaj; Wallin, Anders
- Abstract
This study examines the intra-individual stability of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) over 2 years in 83 patients with mild cognitive impairment (MCI) and 17 cognitively healthy control individuals. All participants underwent clinical and neuropsychological evaluation and lumbar puncture at baseline and after 2 years at a university hospital memory clinic. CSF was analyzed for total tau (T-tau), phospho-tau(181) (P-tau(181)) and amyloid-beta(1-42) (Abeta(1-42)). During the 2-year observational time, 12 MCI patients progressed to AD and 3 progressed to vascular dementia, while 68 remained stable. Baseline T-tau and P-tau(181) levels were elevated in the MCI-AD group as compared to the stable MCI patients and the control group (p<0.01), while baseline Abeta(1-42) levels were lower (p<0.001). Stable MCI patients were biochemically indistinguishable from controls. The biomarker levels at baseline and after 2 years showed Pearson R values between 0.81 and 0.91 (p<0.001) and coefficients of variation of 7.2 to 8.7%. In conclusion, intra-individual biomarker levels are remarkably stable over 2 years. Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials.
- Publication
Journal of Alzheimer's disease : JAD, 2007, Vol 12, Issue 3, p255
- ISSN
1387-2877
- Publication type
Journal Article
- DOI
10.3233/jad-2007-12307