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- Title
Elimination of Amyloid beta Neurotoxicity.
- Authors
Blanchard, Barbara J.; Hiniker, Anne E.; Lu, Connie C.; Margolin, Yelena; Yu, Amy S.; Ingram, Vernon M.
- Abstract
Aggregation of the Alzheimer amyloid beta peptide (Abeta) Abeta1-42 forms neurotoxic fibrils. In contact with human neurons the fibrils cause rapid influx of external calcium through AMPA/kainate-channels. If this molecular mechanism reflects in vivo events, it could explain the pathogenesis of Alzheimer's disease; activation of AMPA/kainate channels is therefore a likely target for therapeutic intervention. Here we show that short antagonistic "decoy peptides", made of D-amino acids, eliminate this "calcium effect" of Ab1-42. Since chronically elevated calcium levels in the disease trigger activation of pathways that lead to neuron dysfunction and cell death, our decoy peptides are obvious candidates for drug development.
- Publication
Journal of Alzheimer's disease : JAD, 2000, Vol 2, Issue 2, p137
- ISSN
1875-8908
- Publication type
Journal Article
- DOI
10.3233/jad-2000-2214