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- Title
Survival of neurally induced mesenchymal cells may determine degree of motor recovery in injured spinal cord rats.
- Authors
Alexanian, Arshak R; Kwok, Wai-Meng; Pravdic, Danijel; Maiman, Dennis J; Fehlings, Michael G
- Abstract
We recently developed a new method for efficient generation of neural-like cells from mice bone marrow (BM)-derived mesenchymal stem cells (MSC) by exposing MSCs to epigenetic modifiers and a neural stem cell environment. These neurally induced MSCs (NI-MSCs) differentiate into neuronal- and glial-like cells in vitro, release neurotrophic factors NGF and BDNF, survive and integrate after transplantation in intact spinal cord. The aim of this study was to determine whether transplanted NI-MSCs survive, differentiate, and integrate in injured spinal cord (ISC) rats and promote functional recovery.
- Publication
Restorative neurology and neuroscience, 2010, Vol 28, Issue 6, p761
- ISSN
1878-3627
- Publication type
Journal Article
- DOI
10.3233/RNN-2010-0547