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- Title
A copper-lowering strategy attenuates amyloid pathology in a transgenic mouse model of Alzheimer's disease.
- Authors
Quinn, Joseph F; Harris, Christopher J; Cobb, Katherine E; Domes, Christopher; Ralle, Martina; Brewer, George; Wadsworth, Teri L
- Abstract
There is increasing evidence for the crucial role of metals in the pathology of Alzheimer's disease. Both the aggregation and neurotoxicity of amyloid-β are dependent on the presence of copper. This study investigated the ability of the copper-complexing drug tetrathiomolybdate to reduce amyloid-β pathology and spatial memory impairment in both a prevention and a treatment paradigm in the Tg2576 mouse model of Alzheimer's disease. Tetrathiomolybdate treatment lowered brain copper and reduced amyloid-β levels in the prevention paradigm, but not in the treatment paradigm. Our data suggests that controlled lowering of systemic copper may achieve anti-amyloid effects if initiated early in the disease process.
- Publication
Journal of Alzheimer's disease : JAD, 2010, Vol 21, Issue 3, p903
- ISSN
1875-8908
- Publication type
Journal Article
- DOI
10.3233/JAD-2010-100408