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- Title
MDM2 amplification is an independent prognostic feature of node-negative, estrogen receptor-positive early-stage breast cancer.
- Authors
Choschzick, Matthias; Heilenkötter, Uwe; Lebeau, Annette; Jaenicke, Fritz; Terracciano, Luigi; Bokemeyer, Carsten; Sauter, Guido; Simon, Ronald
- Abstract
MDM2 is overexpressed and amplified in a number of malignant tumors including breast carcinomas. Cell culture experiments showed a close connection between %of MDM2 expression and estrogen receptor status in breast cancer cell lines. Only little is known about the role of MDM2 amplifications in early-stage breast carcinomas with positive estrogen receptor status.
- Publication
Cancer biomarkers : section A of Disease markers, 2010, Vol 8, Issue 2, p53
- ISSN
1875-8592
- Publication type
Journal Article
- DOI
10.3233/DMA-2011-0806