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- Title
Characterization of Nipah virus from outbreaks in Bangladesh, 2008-2010.
- Authors
Lo, Michael K; Lowe, Luis; Hummel, Kimberly B; Sazzad, Hossain M S; Gurley, Emily S; Hossain, M Jahangir; Luby, Stephen P; Miller, David M; Comer, James A; Rollin, Pierre E; Bellini, William J; Rota, Paul A
- Abstract
Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.
- Publication
Emerging infectious diseases, 2012, Vol 18, Issue 2, p248
- ISSN
1080-6059
- Publication type
Journal Article
- DOI
10.3201/eid1802.111492