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Title
Little evidence for genetic susceptibility to influenza A (H5N1) from family clustering data.
Authors
Pitzer, Virginia E; Olsen, Sonja J; Bergstrom, Carl T; Dowell, Scott F; Lipsitch, Marc
Abstract
The apparent clustering of human cases of influenza A (H5N1) among blood relatives has been considered as evidence of genetic variation in susceptibility. We show that, by chance alone, a high proportion of clusters are expected to be limited to blood relatives when infection is a rare event.