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- Title
West Nile virus infections projected from blood donor screening data, United States, 2003.
- Authors
Busch, Michael P; Wright, David J; Custer, Brian; Tobler, Leslie H; Stramer, Susan L; Kleinman, Steven H; Prince, Harry E; Bianco, Celso; Foster, Gregory; Petersen, Lyle R; Nemo, George; Glynn, Simone A
- Abstract
National blood donor screening for West Nile virus (WNV) RNA using minipool nucleic acid amplification testing (MP-NAT) was implemented in the United States in July 2003. We compiled national NAT yield data and performed WNV immunoglobulin M (IgM) testing in 1 WNV-epidemic region (North Dakota). State-specific MP-NAT yield, antibody seroprevalence, and the average time RNA is detectable by MP-NAT were used to estimate incident infections in 2003. WNV donor screening yielded 944 confirmed viremic donors. MP-NAT yield peaked in August with >0.5% of donations positive for WNV RNA in 4 states. Peak IgM seroprevalence for North Dakota was 5.2% in late September. The average time viremia is detectable by MP-NAT was 6.9 days (95% confidence interval [CI] 3.0-10.7). An estimated 735,000 (95% CI 322,000-1,147,000) infections occurred in 2003, with 256 (95% CI 112-401) infections per neuroinvasive case. In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population.
- Publication
Emerging infectious diseases, 2006, Vol 12, Issue 3, p395
- ISSN
1080-6040
- Publication type
Journal Article
- DOI
10.3201/eid1205.051287