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- Title
Clinical characteristics of the West Nile fever outbreak, Israel, 2000.
- Authors
Chowers, M Y; Lang, R; Nassar, F; Ben-David, D; Giladi, M; Rubinshtein, E; Itzhaki, A; Mishal, J; Siegman-Igra, Y; Kitzes, R; Pick, N; Landau, Z; Wolf, D; Bin, H; Mendelson, E; Pitlik, S D; Weinberger, M
- Abstract
West Nile (WN) virus is endemic in Israel. The last reported outbreak had occurred in 1981. From August to October 2000, a large-scale epidemic of WN fever occurred in Israel; 417 cases were confirmed, with 326 hospitalizations. The main clinical presentations were encephalitis (57.9%), febrile disease (24.4%), and meningitis (15.9%). Within the study group, 33 (14.1%) hospitalized patients died. Mortality was higher among patients >70 years (29.3%). On multivariate regressional analysis, independent predictors of death were age >70 years (odds ratio [OR] 7.7), change in level of consciousness (OR 9.0), and anemia (OR 2.7). In contrast to prior reports, WN fever appears to be a severe illness with high rate of central nervous system involvement and a particularly grim outcome in the elderly.
- Publication
Emerging infectious diseases, 2001, Vol 7, Issue 4, p675
- ISSN
1080-6040
- Publication type
Journal Article
- DOI
10.3201/eid0704.010414