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- Title
The rapid efficacy of abatacept in a patient with rheumatoid vasculitis.
- Authors
Fujii, Wataru; Kohno, Masataka; Ishino, Hidetaka; Nakabayashi, Amane; Fujioka, Kazuki; Kida, Takashi; Nagahara, Hidetake; Murakami, Ken; Nakamura, Kaoru; Seno, Takahiro; Yamamoto, Aihiro; Kawahito, Yutaka
- Abstract
We report a case of rheumatoid vasculitis (RV) that responded well to abatacept, a cytotoxic T lymphocyte-associated antigen 4 (CTLA4)-immunoglobulin fusion protein. A 38-year-old woman developed RV despite treatment with methotrexate and tumor necrosis factor (TNF) inhibitors. The effects of steroid therapy, immunoabsorption plasmapheresis, and interleukin-6 inhibitor were insufficient, however, administration of abatacept rapidly improved her clinical symptoms with almost normalization of the immunological findings. This is the first published case report of the successful treatment of RV with abatacept.
- Publication
Modern Rheumatology, 2012, Vol 22, Issue 4, p630
- ISSN
1439-7595
- Publication type
Academic Journal
- DOI
10.3109/s10165-011-0559-8